In 2005, Jackman filmed the parts of three different characters in Darren Aronofsky's 2006 science-fiction film The Fountain. As Tommy Creo, a neuroscientist, Jackman plays a man who was torn between his wife, Izzi (Rachel Weisz) who is dying of a brain tumor, and his work at trying to cure her. As Captain Tomas Creo, Jackman plays a Spanish Conquistador in the year 1532, Savile, Spain who is seeking the mythical Tree of Life for his Queen, Isabel (also played by Weisz) in order to retain her throne. Captain Tomas is actually a character in the book Izzi is writing called The Fountain. Jackman's third character is the future astronaut, Tom, travelling to a golden nebula in an eco-spacecraft and seeking to be reunited with Izzi. Jackman said The Fountain was his most difficult film thus far, due to the physical and emotional demands of the part.