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Q.

What is the cause Alzheimer's disease?

Asked by samson aseervatham, 02 Nov '08 09:41 pm
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Answers (5)

 
1.

Scientists believe that for most people, Alzheimer's disease results from a combination of genetic, lifestyle and environmental factors that affect the brain over time.

Less than 5 percent of the time, Alzheimer's is caused by specific genetic changes that virtually guarantee a person will develop the disease.

Although the causes of Alzheimer's are not yet fully understood, its effect on the brain is clear. Alzheimer's disease damages and kills brain cells. A brain affected by Alzheimer's disease has many fewer cells and many fewer connections among surviving cells than does a healthy brain.

As more and more brain cells die, Alzheimer's leads to significant brain shrinkage. When doctors examine Alzheimer's brain tissue under the microscope, they see two types of abnormalities that are considered hallmarks of the disease:

Plaques. These clumps of a protein called beta-amyloid may damage and destroy brain cells in several ways, including interfering with cell-to-cell communic ...more
Answered by anil garg, 21 Dec '13 08:27 pm

 
  
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2.

Alzheimer's disease
From Wikipedia, the free encyclopedia
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"Alzheimer" redirects here. For other uses, see Alzheimer (disambiguation).
Alzheimer's disease
Classification and external resources

Comparison of a normal aged brain (left) and an Alzheimer's patient's brain (right). Differential characteristics are pointed out.
ICD-10 G30., F00.
ICD-9 331.0, 290.1 ...more
Answered by pawan bhalla, 23 Jan '09 08:56 pm

 
  
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3.

Three major competing hypotheses exist to explain the cause of the disease. The oldest, on which most currently available drug therapies are based, is the cholinergic hypothesis, which proposes that AD is caused by reduced synthesis of the neurotransmitter acetylcholine. The cholinergic hypothesis has not maintained widespread support, largely because medications intended to treat acetylcholine deficiency have not been very effective. Other cholinergic effects have also been proposed, for example, initiation of large-scale aggregation of amyloid,[50] leading to generalised neuroinflammation.[51]

In 1991, the amyloid hypothesis postulates that amyloid beta (Aβ) deposits are the fundamental cause of the disease.[52][53] It is a compelling theory because the gene for the amyloid beta precursor (APP) is located on chromosome 21, and people with trisomy 21 (Down Syndrome) who thus have an extra gene copy almost universally exhibit AD by 40 years of age.[54][55] Also APOE4, the major ...more
Answered by siddhartha das, 02 Nov '08 10:08 pm

 
  
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4.

Not really known
Answered by Satish, 02 Nov '08 09:47 pm

 
  
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5.

Oldage and senelity
Answered by narayanan, 02 Nov '08 09:42 pm

 
  
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