Earlier there was only Dapsone. Now doctors actually go for multi-drug therapy.

dapsone is the only one I've heard of too, but if you know of anyone afflicted with the illness, I would strongly urge you to get them to visit a skin specialist. There are at least two types of leprosy and although medications may be the same or similar the administration of these drugs and treatment would vary based on the severity of the disease and it's advancement. Supervised medication is a must.

Indian scientist Shantaram Yawalkar and his colleagues formulated a combined therapy using rifampicin and dapsone, intended to mitigate bacterial resistance. Multidrug therapy (MDT) and combining all three drugs was first recommended by a WHO Expert Committee in 1981. These three anti-leprosy drugs are still used in the standard MDT regimens. None of them are used alone because of the risk of developing resistance.