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Over view of Istanbul:
Many of Istanbul's top sights such as Topkapi Palace, Hagia Sophia, the Blue Mosque and the Hippodrome, are in Sultanahmet, as there are many good hotels, including charming Ottoman inns.
Istanbul's Grand Bazaar is just a 12- to 15-minute walk or short tram ride west of Sultanahmet along the old Roman road.
Most 4-star and 5-star hotels are near Taksim Sqaure in Beyoglu, or on the Bosphorus
You can see Istanbul's top sights in a rush on an overnight stay, but you'll need at least 2 days to do them justice, and 3 or 4 days to really get a sense of the city. In a week, you can get a good look at most of what Istanbul has to offer, do some shopping and enjoy an excursion as well.
Be sure to take some time to just sit at a sidewalk cafe and sip Turkish tea or coffee, or go native and smoke a nargile (water pipe). Dine on savory Turkish cuisine in an excellent Istanbul Restaurant; consume a traditional fish sandwich by the Golden Horn,

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