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How Puromycin inhibits translation of both prokaryotes and eukaryotes?

Asked by jeniffer, 05 Oct '08 09:54 pm
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Antibiotics are biochemically or fungally produced substances that inhibit the growth of other organisms. Most antibiotics, like many pharmaceuticals, block translation in protein synthesis. These substances are effective because they take advantage of the tremendous complexity involved in the synthesis of proteins. The following is a table of some of these synthesis inhibitors, the systems they act on, and their mode of action.Puromycin, whose chemical structure was first noted in 1950 by Yarmolinsky and de la Haba, is an antibiotic critical to many studies because of its effect on both prokaryotic and eukaryotic cells. (2) .It is a structural analog of the aminoacyl-adenylyl grouping characteristic of the 3' -end of aminoacyl tRNAs. One of the most striking differences between the two molecules is the adenine moiety carries two methyl groups on its amino nitrogen, and the tyrosyl residue, which forms the amino acid residue, is also methylated in its phenolic oxygen group (2). Anothe ...more
Answered by Pardeep kapoor, 05 Oct '08 10:13 pm

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